RESUMO
Chronic administration of oxytetracycline (OXT) (incorporated at a level of 0.05 g per kg of feed for 50 days) to pigeons, significantly decreased total leukocyte and lymphocyte counts, increased heterophil:lymphocyte ratio and lysosomal enzyme activity, and decreased reticuloendothelial system function compared with controls. Coadministration of black seed (BS) at a level of 2.5% with OXT completely blocked the effects elicited by OXT and produced immunostimulant effects in pigeons. The addition of BS to feed of pigeons could act as an immunoprotective agent when chronic administration of antibiotics are considered.
Assuntos
Adjuvantes Imunológicos/farmacologia , Antibacterianos/farmacologia , Leucócitos/efeitos dos fármacos , Nigella sativa/química , Oxitetraciclina/farmacologia , Adjuvantes Imunológicos/administração & dosagem , Animais , Antibacterianos/administração & dosagem , Columbidae/imunologia , Contagem de Leucócitos , Lisossomos/efeitos dos fármacos , Lisossomos/enzimologia , Oxitetraciclina/administração & dosagem , Sementes/químicaAssuntos
Doenças das Aves/epidemiologia , Criptosporidiose/veterinária , Aves Canoras/parasitologia , Animais , Animais Domésticos , Doenças das Aves/parasitologia , Doenças das Aves/transmissão , Criptosporidiose/epidemiologia , Criptosporidiose/transmissão , Cryptosporidium/isolamento & purificação , Reservatórios de Doenças/veterinária , Humanos , Oocistos/isolamento & purificação , Arábia Saudita/epidemiologiaRESUMO
Administration of either 0.001 g/kg ampicillin (A), 0.05 g/kg oxytetracycline (O) or 0.05 g/kg sulphadimidine (S) in feed to broiler chicks for 50 days caused an increased serum concentration of the drug compared to the control birds that were given no drugs. O and S but not A resulted in a significant decrease of the total number of leukocytes, lymphocytes and the size of bursa of Fabricius and thymus but not spleen or body weight. The antibacterials significantly reduced the macrophage phagocytic activity compared to controls. It is suggested that the prolonged administration of O and S to chickens may induce an immunosuppressant effect.
